Alere™ Toxicology

Since 1978, Alere™ Toxicology has provided excellent substance abuse testing solutions, providing timely and accurate services that deter and detect drug and alcohol abuse. Alere™ Toxicology is a single-source solution for quality analysis that includes laboratory testing services and point of care testing.

Along with laboratory testing for substances of abuse, Alere™ Toxicology offers a wide range of point of care testing devices that provide reliable, cost-effective, and rapid testing for substances of abuse on-site. The current inventory includes over 300 configurations of drug, alcohol, and specimen validity testing devices and a catalog of ancillary supplies, collection kits, chain of custody forms, and shipping supplies. In addition to providing these products, Alere™ Toxicology uses its industry experience to deliver the same technical information and service that clients have come to expect from our laboratory services.

Rapid Screening Devices

Only Alere Toxicology can provide the products you need with the service you deserve. Their resources enable you to implement and manage a rapid on-site screening program.

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PRODUCTS

 

Reliable, immediate test results at the point of care enable you to make informed decisions about substance abuse issues that could compromise the safety of patients, employees, and business. Our rigorous manufacturing standards ensure you receive the best possible products and support resources.

 

Professional Screening Devices

Urine Screening Devices

Select from the industry's widest variety of dip, cassette, and all-inclusive cup designs. We offer multiple drug configurations that are FDA 510(k) cleared-to-market, along with many CLIA-waived devices that are ideal for clinical use.

Alcohol Screening Devices

Multiple device options are available for breath and saliva screening of alcohol, including some that are DOT approved. In a few simple steps, alcohol-screening results can be obtained at any location.

 

LAB SERVICES

Urine Drug Testing Services

Alere Toxicology analyzes urine specimens for substances of abuse in ways that will stand up to any challenge. State-of-the-art technology, automated computer systems, and a skilled laboratory staff ensure accurate analysis.

Oral Fluid Testing Services

Oral fluid testing is recognized as a reliable and innovative test format that provides fast and convenient specimen collections. The non-invasive method does not require special collection facilities necessitated by the privacy requirements of a urine collection. Additionally, because each collection can be directly observed, donor tampering with the specimen is virtually eliminated.

Hair Testing

Hair testing for drugs of abuse is available through Alere Toxicology. Hair testing shows long-term substance use over a period of months.

 


 

Having proper knowledge of substances of abuse and testing program protocols can increase the success of implementing and maintaining drug-free environments. We understand all aspects of administering drug and alcohol testing, and offer a complete list of ancillary resources.

External signs:
-Advanced or unnatural bent pupils
-Red or a faint eye color of eyes, funny and unintelligible speech
-State of inebriation, odorless alcohol
-impaired coordination of movements
-anxiety, "confinement in itself" or overactivity
Certain facts/features:
-signs of nicks, cuts, bruises
-tubes from paper or foil
-small scoops, capsules, vials, bags, tablets (with unknown content) powders
Behavior change:
-growing indifference, loss of interest in the problems in the family
-frequent absences from home and escape from school
-deterioration of memory, inability to concentrate
-alternating insomnia and drowsiness
-hypersensitivity to criticism, unmotivated aggression
frequent and sudden change of mood
-more frequent requests for money or appearance of amounts with vague origin
-disappearance from home values, books,clothes and other
-frequent and unexplained phone calls

Tests of "Alere" are intended to determine the quantities of opiate, narcotic substances in specimens of human urine and saliva. Below is a sample with the limit concentrations for each drug, the presence of which is established by these tests.

AMP-Amphetaminesare a set of powerfulsympathicominetic tools with therapeutic application. The most prevalent of amphetamines are d-amphetamine and amphetamine, 1-d, they are mainly stimulants of the central nervous system causing neurotransmitters and the secretion of epinephrine, norepinephrine, and dopamine in the brain and the body – leading to euphoria, excitement with a feeling of virility, confidence and mobility. Chronic abuse of amphetamines leads to tolerance and habituation to the opiate effect. The cardiovascular system responds to amphetamine with an increase in blood pressure and arrhythmia, it causes more anxiety, feelings of fear, paranoia, hallucinations and damage to nerve cells, causing strokes. Amphetamine is metabolized in many tracks. To a greater extent the sour urine helps to release excretion, such as alkali obstruct it. For 24 hours, approximately 79% of amphetamine is excreted in the urine and about 45% in alkaline. Characteristic is also the release of 20% unchanged, untapped amphetamine. This amount can be found in 1-2 days after its use.

MTD-Methadoneis a synthetic opiate that is clinically available is used clinically for the treatment of pain, as well as in addition to programs for addicted to morphine and heroin. Methadone acts on the central nervous and cardiovascular systems as causing respiratory and circular suppressor. Methadone also causes miozis and increasing muscle tone in the lower gastrointestinal tract, while decreased the amplitude of contractions. Taken in high doses causes sharp analgesia, sedation, respiratory inhibition and coma. After the adoption of the methadone, the main ingredients are emitted into the urine and its metabolites, methadone, EDDP and EMPD. Usually at the time of acceptance of the oral dose of 5 mg methadone and EDDP account for 5% of the dose in the urine for 24 hours. In cases of concomitant therapy, methadone may amounts to 5-50% of the dose in the urine for 24 hours and EDDP may amounts to 3-25% of the dose.

COC-Cocaineis extracted from the leaves of the plant coca. Cocaine is a strong central nervous system stimulant as good as local anesthetic. Some of the psychological effects caused by the impact of cocaine are euphoria, confidence and a sense of increased energy accompanied by a rapid heart rate, rapid heart rate, elevated blood pressure, dilated, tremor and profuse sweating. Prolonged intake of cocaine can lead to addiction and mental dependence. Snorting cocaine is usually less often inject, smoke and rubbed into the gums. He is thrown into the urine as benzoilekronin in a short period of time. Benzoilekronin″t's biological life cycle from 5 to 8 hours which are quite a bit more than those of Cocaine – 0.5 – 1.5 hours as a general it would be possible to be detected for 12 to 72 hours after use or its discovery.

MET-Metamfetamin″tis the most popular synthetic produced by amphetamines and is a strong stimulant with sympathicominetic therapeutic applications. Its adoption in large doses resulted in stimulation of the central nervous system and induce euphoria, confidence, decreased appetite, gives a burst of energy and force. Also causes paranoia, anxiety and heart arrhythmia. He is expelled in the urine as amphetamine and oxidised and deaminirate derivatives sometimes 10 to 40% of it is discharged in the urine as untapped. He usually is found in the urine for about 3 to 5 days after its use.

MOP-MorphineOpioid analgesics – incorporate wide substance group, controlling pain and suppression of the nervous system. Their continued use leads to habituation and may cause disturbances in coordination, to suppress the determination, leads to hypothermia and coma. Morphine is thrown away as non metabolized in urine Morphine and Morphine- glucuronide are available in the urine for several days after the use of opioid dose.

THC-Marijuana-tool having a number of biological effects in humans and is also called Cannabinoid. It acts as a stimulant of the central nervous system, elevates mood, sensitivity and sensuousness, causes poor coordination, memory loss, paranoia, anxiety, depression, hallucinations and rapid heartbeat. Large doses of cannabinoid may lead to dependency and addiction. Tolerating of cardiac and psychotropic substances can lead to permanent looseness , insomnia, anorexia and nouseya. THC is the main active ingredient in cannabinoids. The main metabolite in the urine is 11-nor-9-THC-9-SOON, and can be found hours after use or are detectable in the urine for 3 to 10 days after smoking.

MDMA-Ecstasy
MDMA (3,4-methylene-dioksi-meta-amphetamine), the most popular under the name Ecstasy. MDMA is a synthetic entactogens from the family of phenethylamines (which include mescaline, 2C-I, amphetamine). Its main effect is to increase nasekreciâta and inhibition (suspension) on the return of huge amounts of serotonin, dopamine and norepinephrine in the brain, causing a general feeling of openness, empathy, energy and sense of well-being. The senses has been improved, making it more pleasant physical contact with others, but contrary to myth, it is in itself not an aphrodisiac properties. Dehydration is a risk among most members who are physically active, since the drugs may mask the normal feeling of exhaustion and thirst. For the opposite (water intoxication) was also reported. But the biggest danger that lies behind the Ecstasy is the fact that other, more dangerous substances often mix with it or directly sold to Ecstasy. The long-term effects of its use in people are subject to a lot of disputes mainly because of the risks of depression, due to the reduced levels of serotonin as a result of depleted stocks.

BZO-Benzodiazepine
Benzodiazepine class e psychoactive substance with hallucinogenic sedative, anxiolytic, and anti convulsions effect. Benzodiazepins preparations acting on the central nervous system, reduce anxiety and panic attacks, panic disorder, agoraphobia, relieve insomnia. [1]. In addition to having efficient means against insomnia and treatment of mental anxiety, preparations of this type are used in epileptic seizures, muscle spasms, and also in the treatment of Syndrome of physical dependence (alcoholism and drug addiction).

PCP-Pcp (Angel dust)
PCP (Rhencyclidine) is a synthetic drug from the class of dissociative anaesthetics. The most common is called angel dust, slang, Crystal, embalming fluid, rocket fuel. Probably best known around the noise raised around him at the end of the 1970’s. Then the media present it as an extremely dangerous chemical inducing insanity, psychotic reactions and superhuman strength.

It is found in various forms – crystals, powders, tablets and as a liquid. Recently sold on the illicit market as cigarettes with tobacco or cannabis dipped in liquid PCP. In these cases it is commonly sold as something else, such as PCP.

BAR – Barbiturates
Barbiturate-barbiturates, honey are a group of substances, derivatives of barbituric acid, acting as a depressant of the central nervous system, and by virtue of that, they have a wide range of effects, from mild sedative to anesthesia.

Principles
Each tape or card from is based on specific immunochemical reaction between antibodies and antigens to analyze particular specific ingredient of specimen of human urine. The slide inside counts competition for the binding of the antibodies. When a drug is present in the specimen of urine it competes with medicinal compounds for the limited quantity of antibody-stained compound. When the amount of medicine is equal to or more than the permitted limit it will prevent connection of that of opioid drug combination with antibodies. Therefore, a positive a specimen of urine will not display a colored band in the test zone, marking a positive result while the presence of a colored bar indicates or implies a negative result.
The control line is present in order to serve as a control over the procedure. This colored bar should always be displayed on the control line if the test device is kept in good condition and the test is done properly.

Packing: box of 25 test strips and maps

Submitted materials:

Instruction for use


Storage and stability:
The test must be kept at a temperature from 2 to 30 degrees and will be effective until the date of expiry

Precautions:
1. It is used for in vitro diagnosis or for legal, judicial expertise.
2. Do not use the product after the date of the expiry date.
3. Handle all specimens as if they were potentially infectious
4. Do not open the metal, foil box until you are ready for the test
5. Use a new urine specimen cup for each sample to avoid cross-contamination.

Collection of specimens and preparation:
Fresh urine does not require any special handling or pretreatment. If the quantitative analysis is not carried out immediately the specimen of urine can be frozen or placed in a refrigerator at 2 to 8 degrees for a maximum of 7 days or frozen. Specimens must be allowed to reach room temperature prior to testing. Specimens of urine, which show increased sediment or turbidity should be centrifuged or be left to precipitate before testing.

Quality control:
Control bar is an internal control reagent and the procedure. It will appear if the test was performed correctly and reagents are reactivated.
Control standards can be used to validate the performance of reagents and to establish the reliability of the test. The controls are not submitted together with this test can be purchased.


Interpretation of results:
Negative:two colored bands. The emergence of two colored bands in one line of the test area and one in the zone of the control line indicates negative results. The negative result indicates the absence of opiates in the specimen. It only indicates that the level of drug in the specimen is less than the permissible level.
Positive:One colored band appears in the control line. Not detectable colored bar at the test line. This is an indication that the level of drug in the urine specimen is over the permitted limit.
Invalid: If no colored band in the control line – the test result is invalid. Test the sample again with a new test device.

Note:Very lightly colored tape in the area of the test line indicates that the amount of amphetamine in the sample is near the level of allowable limit. These specimens and other positive samples must be confirmed through the use of an alternative method such as GC/MS.

Expected results:
He identified the drugs in human urine in their concentration near or above the permitted limit. The concentration of the drugs cannot be estimated by this analysis. The test is designed to be distinguished the negative result of the alleged positive result. All positive results should be confirmed by an alternative method is used preferably GC/MS.

 

Sava Medical Ltd.

Bank account in BGN:
IBAN: BG85FINV91501015977178
BIC FINVBGSF First Investment Bank
VAT (ID) number under VAT Law: BG202696081
UIN: 202696081

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